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RESEARCH PRODUCT
The role of network connectivity on epileptiform activity.
Giuseppe GiacopelliGiuseppe GiacopelliMichele MiglioreDomenico TegoloDomenico Tegolosubject
Computer scienceScienceAction PotentialsCellular levelArticleFunctional networksComputational biophysicsSeizuresNeural Pathwayscomputational model networkHumansThe role of network connectivity on epileptiform activityComputational modelMultidisciplinaryNetwork modelsEpilepsycellular network connectivitySettore INF/01 - InformaticaQRBrainElectroencephalographyNetwork connectivityApplied mathematicsepileptiform activitywiring propertieCellular networkKey (cryptography)MedicineNerve NetNeurosciencedescription
AbstractA number of potentially important mechanisms have been identified as key players to generate epileptiform activity, such as genetic mutations, activity-dependent alteration of synaptic functions, and functional network reorganization at the macroscopic level. Here we study how network connectivity at cellular level can affect the onset of epileptiform activity, using computational model networks with different wiring properties. The model suggests that networks connected as in real brain circuits are more resistant to generate seizure-like activity. The results suggest new experimentally testable predictions on the cellular network connectivity in epileptic individuals, and highlight the importance of using the appropriate network connectivity to investigate epileptiform activity with computational models.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2021-01-01 | Scientific reports |