Ceļa un gūžas locītavas osteoartrīta ārstēšana izmantojot kaula smadzeņu mononukleārās šūnas

6533b7d4fe1ef96bd126370d

RESEARCH PRODUCT

Ceļa un gūžas locītavas osteoartrīta ārstēšana izmantojot kaula smadzeņu mononukleārās šūnas

Valdis Gončars

subject

Orthopedics Ortopēdija Medicīna

description

Tika pētīta ceļa un gūžas locītavas osteoartrīta (OA) agrīno stadiju ārstēšana ar sarkano kaula smadzeņu mononukleārām šūnām (KS-MNŠ). Pēc to intraartikulāras injekcijas tika vērtētas OA simptomu un locītavas audu struktūru izmaiņas 32 pacientu grupai ar ceļa un 27 pacientu grupai ar gūžas OA. Klīniskie rezultāti un strukturālās izmaiņas tika izvērtēti 12 mēnešu periodā. Netika novērotas nevēlamas blakusparādības. Tika konstatēts pacientu klīniskā stāvokļa uzlabojums. Salīdzinot ar kontroles grupu, bija vērojams statistiski nozīmīgs pārsvars sāpju mazināšanā KS-MNŠ grupas pacientiem. Magnētiskās rezonanses izmeklējumos tika novērots uzlabojums mazinot kaula smadzeņu tūsku un locītavas skrimšļa deģeneratīvās izmaiņas Secinājumi: vienreizēja (KS-MNŠ) injekcija ir droša ārstēšanas metode, kas mazina ceļa un gūžas locītavas II-III stadijas osteoartrīta klīniskos simptomus un daļā gadījumu deģeneratīvās izmaiņas locītavu veidojošajos audos 12 mēnešu periodā.

year	journal	country	edition	language
2019-01-01

https://dspace.lu.lv/dspace/handle/7/48859

PEPhysical Sciences and Engineering
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SHSocial Sciences and Humanities
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