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RESEARCH PRODUCT

Role of Single Low Pulse Intensity of Transcranial Magnetic Stimulation Over the Frontal Cortex for Cognitive Function

Fawaz Al-hussainGhadah Faisal ShareefiShahid BashirWoo-kyoung YooAli HamzaTurki Abualait

subject

medicine.medical_specialtysubthreshold TMSFrontal cortexcognitive functionsmedicine.medical_treatmentStimulationAudiologybehavioral disciplines and activities050105 experimental psychologylcsh:RC321-57103 medical and health sciencesBehavioral Neuroscience0302 clinical medicineNeuromodulationmedicine0501 psychology and cognitive sciencesPulse intensitylcsh:Neurosciences. Biological psychiatry. NeuropsychiatryBiological PsychiatryOriginal Researchdorsolateral prefrontal cortexbusiness.industryCambridge Neuropsychological Test Automated Battery05 social sciencesmonophasic TMSCognitionHuman NeuroscienceTranscranial magnetic stimulationDorsolateral prefrontal cortexPsychiatry and Mental healthNeuropsychology and Physiological Psychologymedicine.anatomical_structureNeurologynervous systemneuromodulationbusiness030217 neurology & neurosurgerypsychological phenomena and processes

description

Background: The principal aim of this study was to measure the effect of online single-pulse transcranial magnetic stimulation (TMS) over the right dorsolateral prefrontal cortex (DLPFC) on cognition via the Cambridge Neuropsychological Test Automated Battery (CANTAB) in healthy individuals. Methods: In a single-blind, sham-controlled study, we assessed both 50% and 60% of the resting motor threshold (RMT) over the right DLPFC in healthy right-handed (n = 42) adults using cognitive function, such as attention and memory, as a measure via CANTAB. Results: We observed an improvement in the cognitive function level during the use of online low intensities of 50% and 60% RMT active stimulation of the DLPFC compared to the sham stimulation. Conclusions: The results showed that low-intensity TMS can indeed effectively modulate cognitive function in DLPFC. Future research is, however, necessary to investigate the potential effects of low-intensity TMS on different brain areas to increase confidence in the observed results.

yearjournalcountryeditionlanguage
2020-07-01Frontiers in Human Neuroscience
10.3389/fnhum.2020.00205http://europepmc.org/articles/PMC7350777