Potential effects of age-associated oxidative stress on mammalian oocytes/embryos

6533b7d5fe1ef96bd1263db3

RESEARCH PRODUCT

Potential effects of age-associated oxidative stress on mammalian oocytes/embryos

subject

Adult Fetal Proteins Embryology Biology medicine.disease_cause DNA Mitochondrial Congenital Abnormalities Mice chemistry.chemical_compound Adenosine Triphosphate Neoplasms Genetics medicine Animals Humans Molecular Biology Cellular Senescence Cytoskeleton Mammals Egg Proteins Embryogenesis Obstetrics and Gynecology Embryo Cell Biology Glutathione Embryo Mammalian Oocyte Glutathione Cell biology Oxidative Stress Cytosol Fertility medicine.anatomical_structure Reproductive Medicine Biochemistry chemistry Ageing Fertilization Oocytes Reactive Oxygen Species Oxidation-Reduction Intracellular Oxidative stress Maternal Age Developmental Biology

description

This bioessay aims to explain the different effects of maternal ageing and postovulatory oocyte ageing on mammalian oocytes/embryos under the scope of 'the oxygen radical-mitochondrial injury hypothesis of ageing'. This hypothesis assumes a key role in the senescent process of oxygen radical damage to mitochondrial DNA, proteins and lipids. It is proposed that a decrease in intracellular ATP concentrations and glutathione (GSH)/glutathione disulphide (GSSG) ratio together with a concomitant increase in cytosolic Ca2+ are major factors causing the observed detrimental effects of ageing on cytoskeletal fibres, fertilization and embryo development.

year	journal	country	edition	language
1996-10-01	Molecular Human Reproduction

https://doi.org/10.1093/molehr/2.10.717

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