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RESEARCH PRODUCT
NFAT transcription factors in control of peripheral T cell tolerance.
Edgar SchmittTobias BoppEdgar SerflingMichael StassenAlois PalmetshoferStefan Klein-hesslingsubject
Clonal AnergyClonal anergyNFATC Transcription FactorsT cellT-LymphocytesUbiquitin-Protein LigasesImmunologyPeripheral toleranceNFATForkhead Transcription FactorsBiologyNFATC Transcription FactorsAcquired immune systemCell biologyAutoimmune DiseasesCalcineurinMicemedicine.anatomical_structuremedicineImmune ToleranceImmunology and AllergyAnimalsHumansTranscription factordescription
The Ca++-regulated calcineurin/NFAT cascade is one of the crucial signalling pathways that controls adaptive immunity. However, a number of novel experimental data suggest that, in addition to their role in T cell activation, NFATc transcription factors play also a decisive role in the generation of peripheral tolerance against self-antigens. This function of NFATc factors is mediated by controlling activation-induced cell death and clonal anergy of T helper cells and the activity of regulatory T cells. The multi-functional role of NFATc proteins characterize these transcription factors as key regulators of immunological tolerance and, if dysregulated, of development of autoimmune diseases.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2006-10-14 | European journal of immunology |