6533b7d5fe1ef96bd1263e6e

RESEARCH PRODUCT

Docking and synthesis of pyrrolopyrimidodiazepinone derivatives (PPDs) and their precursors: New scaffolds for DNA-interacting agents

Chiara PatellaAntonino LauriaMario IppolitoAnna Maria Almerico

subject

ChemistryStereochemistryBase pairIn silicoIntercalation (chemistry)ChromophoreCondensed Matter PhysicsBiochemistryCombinatorial chemistrychemistry.chemical_compoundDocking (molecular)Side chainDockingDNA interactionPPDIntercalating modeMinor groove modePhysical and Theoretical ChemistryDNAMinor groove

description

New classes of pyrrolopyrimidodiazepinone derivatives (PPDs) and their precursors were studied in silico for their ability to form stable complex with DNA fragment. In the docking studies two binding modes can be envisaged: groove mode and intercalating mode. In the case of the best ligands the docking studies revealed a common binding mode with the chromophore intercalated between GC base pairs whereas the side chain lies close to the minor groove. Synthetic approach to the PPD ring systems is discussed.

yearjournalcountryeditionlanguage
2007-10-01Journal of Molecular Structure: THEOCHEM
https://doi.org/10.1016/j.theochem.2007.05.033