Glioksilāžu sistēmas novērtēšanas metodes cukura diabēta komplikāciju pētījumiem

6533b7d5fe1ef96bd1264105

RESEARCH PRODUCT

Glioksilāžu sistēmas novērtēšanas metodes cukura diabēta komplikāciju pētījumiem

Mārtiņš Strahs

subject

description

Glioksalāžu sistēmas enzīmi reprezentē vienu no šūnas enzimātiskajām aizsardzības sistēmām pret neenzimātisku glikēšanos. Glioksalāžu sistēmu veido divi enzīmi glioksalāze I un glioksalāze II. Glioksalāžu enzīmi pārvērš ļoti reaģēt spējīgos metilglioksālu, glioksālu un citus mazmolekulāros acikliskos α-oksoaldehīdus atbilstošās netoksiskās α-hidroksiskābēs. Darba mērķis bija glioksalāžu laboratoriskās novērtēšanas metožu standartizācija cukura diabēta vēlīno komplikāciju pētījumiem. Tika izstrādāta metode glioksalāzes II aktivitātes noteikšanai, kā arī pētīta glabāšanas temperatūras ietekme uz glioksalāzes II aktivitāti. Jāsecina, ka glioksalāzes I un II aktivitāte, un glioksalāzes I proteīnu daudzums dažādos žurku audos liecina par glioksalāžu sistēmas nozīmīgo lomu cukura diabēta neiropātiju attīstības mehānismos.

year	journal	country	edition	language
2010-01-01

https://dspace.lu.lv/dspace/handle/7/24405

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