6533b7d5fe1ef96bd12643fc

RESEARCH PRODUCT

A single amino acid change A19V in perforin: a novel, frequent predisposing factor to childhood acute lymphoblastic leukemia?

A. SantoroC. Trizzino AL. Lo NigroG. CorselloM. Arico

subject

A91V Childhood acute lymphoblastic leukemia Perrforin

description

We screened 100 children with acute lymphoblastic leukemia (ALL) to assess the incidence of single amino acid change A91V in perform. Heterozygous A91V was found in 12/100 patients and 5/127 controls (OR, 3.4; 95%CI: 1.15-9.95; p=0.014). A91V is a novel and frequent predisposing factor for childhood ALL.

yearjournalcountryeditionlanguage
2005-01-01
http://hdl.handle.net/10447/23242