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RESEARCH PRODUCT
Umbilical Cord Mesenchymal Stromal Cells for Cartilage Regeneration Applications
E. RussoM. CaprndaP. KruzliakP. G. ConaldiC. V. BorlonganG. La Roccasubject
Settore BIO/17 - IstologiaReview ArticleCell Biologymesenchymal stromal cells stem cells cartilage regenerative medicien tissue engineering immune modulationMolecular BiologyInternal medicineRC31-1245description
Chondropathies are increasing worldwide, but effective treatments are currently lacking. Mesenchymal stromal cell (MSCs) transplantation represents a promising approach to counteract the degenerative and inflammatory environment characterizing those pathologies, such as osteoarthritis (OA) and rheumatoid arthritis (RA). Umbilical cord- (UC-) MSCs gained increasing interest due to their multilineage differentiation potential, immunomodulatory, and anti-inflammatory properties as well as higher proliferation rates, abundant supply along with no risks for the donor compared to adult MSCs. In addition, UC-MSCs are physiologically adapted to survive in an ischemic and nutrient-poor environment as well as to produce an extracellular matrix (ECM) similar to that of the cartilage. All these characteristics make UC-MSCs a pivotal source for a stem cell-based treatment of chondropathies. In this review, the regenerative potential of UC-MSCs for the treatment of cartilage diseases will be discussed focusing on in vitro, in vivo, and clinical studies.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2022-01-06 | Stem Cells International |