6533b7d5fe1ef96bd126473c
RESEARCH PRODUCT
Genome size reduction through multiple events of gene disintegration in Buchnera APS
Amparo LatorreFrancisco J. SilvaAndrés Moyasubject
GeneticsGenome evolutionPseudogeneBacterial genome sizebiochemical phenomena metabolism and nutritionBiologybiology.organism_classificationBiological EvolutionGenomeBuchneraEscherichia coliGeneticsMinimal genomeBuchneraVibrio choleraeGeneGenome sizeGene DeletionGenome BacterialPseudogenesdescription
The evolution of the endosymbiont Buchnera during its adaptation to intracellular life involved a massive reduction in its genome. By comparing the orthologous genes of Buchnera, Escherichia coli and Vibrio cholerae, we show that the minimal genome size of Buchnera arose from multiple events of gene disintegration dispersed over the whole genome. The elimination of the genes was a continuous process that began with gene inactivation and progressed until the DNA corresponding to the pseudogenes were completely deleted.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2001-11-01 | Trends in Genetics |