6533b7d5fe1ef96bd1264768
RESEARCH PRODUCT
Exhaustive physical exercise causes oxidation of glutathione status in blood: Prevention by antioxidant administration
Jose ViñaTadayasu FurukawaFerrero JaMiguel AsensiJuan SastreFederico V. PallardóEsperanza Gascosubject
Malemedicine.medical_specialtyAntioxidantPhysiologymedicine.medical_treatmentPhysical ExertionPhysical exerciseRedoxAntioxidantschemistry.chemical_compoundPhysiology (medical)Internal medicinePyruvic AcidmedicineAnimalsHumansLactic AcidPyruvatesChemistryMetabolismGlutathioneGlutathioneLactic acidEnzymesRatsEndocrinologyOral vitaminLactatesPyruvic acidOxidation-Reductiondescription
We have studied the effect of exhaustive concentric physical exercise on glutathione redox status and the possible relationship between blood glutathione oxidation and blood lactate and pyruvate levels. Levels of oxidized glutathione (GSSG) in blood increase after exhaustive concentric physical exercise in trained humans. GSSG levels were 72% higher immediately after exercise than at rest. They returned to normal values 1 h after exercise. Blood reduced glutathione (GSH) levels did not change significantly after the exercise. We have found a linear relationship between GSSG-to-GSH and lactate-to-pyruvate ratios in human blood before, during, and after exhaustive exercise. In rats, physical exercise also caused an increase in blood GSSG levels that were 200% higher after physical exercise than at rest. GSH levels did not change significantly. Thus, both in rats and humans, exhaustive physical exercise causes a change in glutathione redox status in blood. We have also found that antioxidant administration, i.e., oral vitamin C, N-acetyl-L-cysteine, or glutathione, is effective in preventing oxidation of the blood glutathione pool after physical exercise in rats.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 1992-11-01 |