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RESEARCH PRODUCT
The future: critical knowledge about anti-itch therapy.
Fabrizio GuarneriGiuseppe TerranovaClaudio GuarneriMargherita Terranovasubject
medicine.medical_specialtybusiness.industryNarcotic AntagonistsPruritusSymptomatic treatmentSingle factorDermatologyGeneral MedicineAntipruriticsMultidisciplinary approachImmunologyNeural PathwaysmedicineHumansDrug Therapy CombinationProtease InhibitorsCapsaicinIntensive care medicinebusinessdescription
: Itch is an extremely frequent and enervating symptom of many diseases. Current anti-itch therapy, which is based almost exclusively on an “immunocentric” viewpoint, is often unsatisfactory. Recent studies show that this symptom is in fact the result of a complex interplay among skin, nervous system, endocrine system, and immune system. This explains the frequent failure of therapeutic strategies focused only on a single factor and suggests the usefulness of a polypharmacologic symptomatic treatment, designed on a case-by-case basis as a result of a multidisciplinary approach. We discuss the perspectives of anti-itch therapy in light of the new pathogenetic and pharmacologic acquisitions.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2005-11-22 | Dermatologic therapy |