6533b7d5fe1ef96bd1264956

RESEARCH PRODUCT

Synthesis of substituted carbamo(dithioperoxo)thioates as potential BCA2-inhibitory anticancer agents

Francesca SolfaHelen L. WigginsKwok Ying Ingrid TsangArwyn Tomos JonesAndrew D. WestwellVincenzo CilibrasiVincenzo CilibrasiMatteo MorelliMatteo Morelli

subject

chemistry.chemical_classificationCarbamo(dithioperoxo)thioateRMCarbon disulfideStereochemistryTetrabromomethaneDrug Discovery3003 Pharmaceutical ScienceOrganic ChemistryTetrabromomethaneCombinatorial chemistryBiochemistrychemistry.chemical_compoundchemistryAnticancer agentDrug DiscoveryBCA2 inhibitorCancer cell linesHuman breastAlkylDisulfiram analogue

description

A new, simple, one-step synthetic route to carbamo(dithioperoxo)thioates from commercially available starting materials is described. The key step of this new synthetic approach involves the tetrabromomethane-promoted reaction between secondary amines, carbon disulfide and alkyl thiols under basic conditions at room temperature. New compounds from this series selected for anticancer screening showed selective sub-micromolar activity within BCA2-expressing human breast cancer cell lines.

yearjournalcountryeditionlanguage
2015-05-01
10.1016/j.tetlet.2015.03.132http://hdl.handle.net/10447/146659