Jauna 1,4-dihidropiridīna atvasinājuma D3-69 ietekme uz atmiņas procesiem žurkām

6533b7d5fe1ef96bd1264b61

RESEARCH PRODUCT

Jauna 1,4-dihidropiridīna atvasinājuma D3-69 ietekme uz atmiņas procesiem žurkām

Lauma Krēsliņa

subject

description

Straujā neirodeģeneratīvo slimību (piemēram, Parkinsona un Alcheimera slimības) izplatības palielināšanās izvirza prasības pēc arvien jaunām farmakoterapijas stratēģijām efektīvu un multifaktoriālu savienojumu sintezēšanā. Rasagilīns un 1,4-dihidropiridīns (DHP) iepriekšējos pētījumos uzrādīja neiroprotektīvas un atmiņu stimulējošas īpašības. Latvijas Organiskās sintēzes institūtā (LOSI) tika sintezēts jauns 1,4-dihidropiridīna atvasinājums ar propargilgrupu – D3-69. Bakalaura darba mērķis bija noteikt D3-69 neiroprotektīvās darbības potenciālu, veicot pasīvās izvairīšanās atmiņas testu veselām žurkām. D3-69 uzrāda statistiski nozīmīgus rezultātus, salīdzinot ar rasagilīnu (standartkontroli), bet salīdzinot ar fizioloģisko šķīdumu (kontroli) neuzrāda tādus. D3-69 uzrāda arī vislielāko latentā perioda starpību, kas liecina par atmiņu uzlabojošām īpašībām. Gan rasagilīna, gan kontroles grupas žurku atmiņa bija pasliktinājusies atkārtotā atmiņas pārbaudē, kamēr D3-69 uzrādīja nemainīgus rezultātus abās reizēs, kas norāda par noturīgu un ilgstošu atmiņu stimulējošu efektu. Atslēgas vārdi: D3-69, atmiņa, neirodeģenerācija, propargilgrupa, 1,4-dihidropiridīni (DHP), rasagilīns, cerebrokrasts

year	journal	country	edition	language
2012-01-01

https://dspace.lu.lv/dspace/handle/7/26376

PEPhysical Sciences and Engineering
- PE2Fundamental Constituents of Matter
  - PE2_1Theory of fundamental interactions
  - PE2_2 Phenomenology of fundamental interactions
  - PE2_3Experimental particle physics with accelerators
  - PE2_4Experimental particle physics without accelerators
  - PE2_6Nuclear, hadron and heavy ion physics
  - PE2_8Gas and plasma physics
  - PE2_5Classical and quantum physics of gravitational interactions
  - PE2_7Nuclear and particle astrophysics
  - PE2_9 Electromagnetism
  - PE2_10Atomic, molecular physics
  - PE2_11Ultra-cold atoms and molecules
  - PE2_18Equilibrium and non-equilibrium statistical mechanics: steady states and dynamics
  - PE2_14Lasers, ultra-short lasers and laser physics
  - PE2_17Metrology and measurement
  - PE2_16Non-linear physics
  - PE2_12Optics, non-linear optics and nano-optics
  - PE2_13Quantum optics and quantum information
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- PE1Mathematics
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  - PE1_11Theoretical aspects of partial differential equations
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  - PE1_19Scientific computing and data processing
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  - PE4_17Characterisation methods of materials
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  - PE6_12Scientific computing, simulation and modelling tools
  - PE6_13Bioinformatics, bio-inspired computing, and natural computing
  - PE6_14Quantum computing (formal methods, algorithms and other computer science aspects)
  - PE6_1Computer architecture, embedded systems, operating systems
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  - PE6_11Machine learning, statistical data processing and applications using signal processing (e.g. speech, image, video)
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  - PE6_4Theoretical computer science, formal methods, automata
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- PE7Systems and Communication Engineering
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  - PE7_2Electrical engineering: power components and/or systems
  - PE7_7Signal processing
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- PE10Earth System Science
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  - PE10_21Earth system modelling and interactions
  - PE10_14Earth observations from space/remote sensing
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- PE11Materials Engineering
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  - PE11_1Engineering of biomaterials, biomimetic, bioinspired and bio-enabled materials
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LSLife Sciences
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  - LS1_5Lipid biology
  - LS1_6Glycobiology
  - LS1_11Chemical biology
  - LS1_12Protein design
  - LS1_13Early translational research and drug design
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  - LS2_3Epigenetics
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  - LS2_4Gene regulation
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  - LS2_6Metagenomics
  - LS2_7Transcriptomics
  - LS2_8Proteomics
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  - LS2_10Glycomics/Lipidomics
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  - LS8_15Theoretical developments and modelling in environmental biology, ecology, and evolution
- LS9Biotechnology and Biosystems Engineering
  - LS9_3Bioengineering of cells, tissues, organs and organisms
  - LS9_2Applied genetics, gene editing and transgenic organisms
  - LS9_4Microbial biotechnology and bioengineering
  - LS9_5Food biotechnology and bioengineering
  - LS9_6Marine biotechnology and bioengineering
  - LS9_7Environmental biotechnology and bioengineering
  - LS9_8Applied plant sciences, plant breeding, agroecology and soil biology
  - LS9_10Veterinary and applied animal sciences
  - LS9_9Plant pathology and pest resistance
  - LS9_11Biomass production and utilisation, biofuels
  - LS9_12Ecotoxicology, biohazards and biosafety
  - LS9_1Bioengineering for synthetic and chemical biology
SHSocial Sciences and Humanities
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  - SH1_5Corporate finance; international finance
- SH3The Social World and Its Interactions
  - SH3_1Social structure, social mobility, social innovation
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- SH4The Human Mind and Its Complexity
  - SH4_1Cognitive basis of human development, developmental disorders; comparative cognition
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  - SH4_11Pragmatics, sociolinguistics, linguistic anthropology, discourse analysis
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- SH6The Study of the Human Past
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  - SH8_9Digital approaches to anthropology, cultural studies and art