6533b7d5fe1ef96bd1265048

RESEARCH PRODUCT

Animal Models of Hypertension

Thomas WallerathUlrich FörstermannBrett M. Mitchell

subject

Nitric oxide synthasebiologybusiness.industryHypertensive animalbiology.proteinMedicineWater chemistryDiseaseRisk factorbusinessBioinformaticsPathophysiology

description

Hypertension affects approximately 25% of adults and is a major risk factor for cardiovascular disease. Although there are currently adequate therapeutic options for humans with hypertension, the molecular mechanisms underlying hypertension are still relatively unknown. The generation of hypertensive animal models provides an excellent modality to not only study the pathophysiology but also test innovative therapeutics. This chapter describes the detailed methods that utilize the drinking water of rats to develop models of nitric oxide synthase (NOS) inhibition-induced, guanosine triphosphate cyclohydrolase (GTPCH) inhibition-induced, and glucocorticoid-induced hypertension.

yearjournalcountryeditionlanguage
2007-01-01
https://doi.org/10.1007/978-1-59745-571-8_6