6533b7d5fe1ef96bd126511a
RESEARCH PRODUCT
Tandem asymmetric Michael reaction-intramolecular Michael addition. An easy entry to chiral fluorinated 1,4-dihydropyridines.
Silvia CatalanAntonio Simón-fuentesMaría Sánchez-rosellóSantos FusteroCarlos Del Pozosubject
chemistry.chemical_classificationModels MolecularDihydropyridinesTandemHydrocarbons FluorinatedMolecular StructureChemistryOrganic ChemistryDiastereomerSulfoxideStereoisomerismBiochemistryCombinatorial chemistryCatalysischemistry.chemical_compoundIntramolecular forceAlkynesMichael reactionOrganic chemistryCombinatorial Chemistry TechniquesPhysical and Theoretical ChemistryAlkyldescription
A novel one-pot tandem asymmetric Hantzsch-type process has been employed to generate fluorinated 1,4-dihydropyridines (1,4-DHPs) as single diastereoisomers. It involves the condensation of (R)-(+)-allyl p-tolyl sulfoxide, fluorinated nitriles, and alkyl propiolates, giving access to a new family of enantiomerically pure fluorine-containing 1,4-DHPs.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2010-01-01 | Organic letters |