6533b7d5fe1ef96bd126524b

RESEARCH PRODUCT

Generation of Cytotoxic T Lymphocytes Against Ly Alloantigen

Hermann WagnerKlaus PfizenmaierA Starzinski-powitzMartin Röllinghoff

subject

IsoantigensCyclophosphamideT-Lymphocytesanimal diseasesImmunologyMice Inbred Strainschemical and pharmacologic phenomenaBiologyMiceImmune systemIn vivomedicineAnimalsCytotoxic T cellAlleleCyclophosphamideAllelesCells CulturedGeneral Medicinebiochemical phenomena metabolism and nutritionCytotoxicity Tests ImmunologicImmunizationImmunologybacteriaImmunizationmedicine.drug

description

Cytotoxic T lymphocytes specific for immune alloantigens controlled by alleles of the Ly system have been induced in vivo. These results were obtained either in a secondary type of response or by treating mice before immunization with a single dose of cyclophosphamide (80 mg/kg).

https://doi.org/10.1111/j.1365-3083.1977.tb00350.x