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RESEARCH PRODUCT
Women Live Longer than Men: Understanding Molecular Mechanisms Offers Opportunities to Intervene by Using Estrogenic Compounds
Jose ViñaConsuelo Borrássubject
MaleAgingmedicine.medical_specialtyAntioxidantFree RadicalsPhysiologymedia_common.quotation_subjectmedicine.medical_treatmentLongevityClinical BiochemistryPhytoestrogensEstrogenic CompoundsBiologyBiochemistryAntioxidantschemistry.chemical_compoundLife ExpectancySex FactorsInternal medicinemedicineAnimalsHumansAnimal speciesMolecular BiologyGeneral Environmental Sciencemedia_commonLife spanLongevityEstrogensCell BiologyOxidative StressEndocrinologychemistrySelective estrogen receptor modulatorGeneral Earth and Planetary SciencesFemalePhytoestrogensdescription
Abstract Women live longer than men. Moreover, females live longer than males in some, but not all, experimental animals. The differences in longevity between genders are related to free radical production. Indeed, females produce less radicals only in animal species in which they live longer than males. This is because estrogens upregulate antioxidant longevity-related genes. These considerations have led us to postulate an extended concept of antioxidant in biology: an antioxidant is any nutritional, physiological, or pharmacological manipulation that increases the expression and activity of antioxidant genes or proteins. Phytoestrogens or other selective estrogen receptor modulators lower age-related diseases and prolong life span, at least in experimental animals. This provides rational bases to study their action in humans further. Antioxid. Redox Signal. 13, 269–278.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2010-01-12 | Antioxidants & Redox Signaling |