6533b7d5fe1ef96bd12652d6

RESEARCH PRODUCT

Drugs Repurposing for Coronavirus Treatment: Computational Study Based On Molecular Topology

Maria Galvez-llompartJorge GalvezRiccardo Zanni

subject

medicine.drug_classAntibiotics2415 Biología MolecularComputational biologymedicine.disease_causeAzithromycinVirus2302.22 Farmacología Molecularchemistry.chemical_compound32 Ciencias MédicasClarithromycinmedicineRepurposingCoronavirus2302.21 Biología MolecularMolecular topology12 Matemáticasbusiness.industryTopología molecularCOVID-19DrugsLopinavirCoronaviruschemistryFármacosBrecanavirbusinessTipología molecularmedicine.drug

description

The present communication illustrates the results of a computational study based on molecular topology, focused on the repositioning of drugs to treat the SARS-CoV-2 virus, better known as coronavirus, responsible for the COVID-19 disease. Using lopinavir, a well-known viral protease inhibitor as the reference drug, a mathematical pattern is found allowing the screening of the market drugs, searching for potential candidates to inhibit the said enzyme. This way new possible therapeutic alternatives to fight the coronavirus are found. Results indicate that antivirals such as brecanavir, as well as various groups of drugs, among which are antibiotics of the macrolide family (azithromycin, clarithromycin and erythromycin among others) could be useful in treating COVID-19 infection. Ciencias Experimentales

yearjournalcountryeditionlanguage
2020-01-01
http://hdl.handle.net/20.500.12466/1179