6533b7d5fe1ef96bd12652fa
RESEARCH PRODUCT
Killed Candida albicans yeasts and hyphae inhibit gamma interferon release by murine natural killer cells.
José-enrique O'connorM. Luisa GilDaniel GozalboEva VillamónCelia Murcianosubject
LipopolysaccharidesHyphaLipopolysaccharideImmunologyHyphaeMicrobiologyNatural killer cellMicrobiologychemistry.chemical_compoundInterferon-gammaMiceImmune systemCandida albicansmedicineAnimalsInterferon gammaCandida albicansbiologyInterleukinsZymosanZymosanbiology.organism_classificationCorpus albicansToll-Like Receptor 2Killer Cells NaturalMice Inbred C57BLToll-Like Receptor 4Infectious Diseasesmedicine.anatomical_structurechemistryParasitologyFungal and Parasitic Infectionsmedicine.drugdescription
ABSTRACT Killed yeasts and hyphae of Candida albicans inhibit gamma interferon secretion by highly purified murine NK cells in response to the Toll-like receptor ligands lipopolysaccharide and zymosan. This effect, which is also observed in the presence of NK-activating cytokines (interleukin-2 [IL-2], IL-12, and IL-15), may represent a novel mechanism of immune evasion that contributes to the virulence of C. albicans .
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2006-02-01 | Infection and immunity |