Omega-(Hetarilamino-N-(1,3-tiazol-2-il)alkānamīdu sintēze un īpašības

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Omega-(Hetarilamino-N-(1,3-tiazol-2-il)alkānamīdu sintēze un īpašības

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Darbā veikta 1,2,3,4-tetrahidro(izo)hinolīna, 5-aminohinolīna un 2-amino(benz)tiazola N-alkilēšanas reakcija ar hloraizvietotiem heterociklu amīdiem dažādos reakcijas apstākļos, ka arī tālāka amīda saites reducēšana iegūtajos savienojumos. Izpētīta 4-hlor-N-(1,3-tiazol-2-il)butānamīda ciklizācijas reakcija un atrasti apstākļi kas ļauj vienkārši un ar augstiem iznākumiem iegūt 1-(1,3-(benz)tiazol-2-il)pirrolidīn-2-onus. Darba rezultātā iegūti jauni, potenciāli bioloģiski aktīvi ω-(hetarilamino)-N-(1,3-tiazol-2-il)alkānamīdi un to analogi, kas satur divu heterociklu atlikumus, dažādās kombinācijās, savienotus ar dažāda tipa saiti. Sintezēto savienojumu struktūras pierādītas ar dažādām fizikāli – ķīmiskām metodēm: elementanalīzi, KMR, IS spektroskopiju un masas spektrometriju.

year	journal	country	edition	language
2012-01-01

https://dspace.lu.lv/dspace/handle/7/22877

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