ChemInform Abstract: Dysidotronic Acid, a New and Selective Human Phospholipase A2 Inhibitor from the Sponge Dysidea sp.

6533b7d6fe1ef96bd12659ff

RESEARCH PRODUCT

ChemInform Abstract: Dysidotronic Acid, a New and Selective Human Phospholipase A2 Inhibitor from the Sponge Dysidea sp.

Miguel Payá Inmaculada Posadas Cécile Debitus Maria Valeria D'auria Clelia Giannini

subject

chemistry.chemical_classification biology Stereochemistry Chemical structure General Medicine biology.organism_classification Terpene Manoalide chemistry.chemical_compound Sponge Enzyme Phospholipase A2 chemistry biology.protein Potency IC50

description

Abstract A new bioactive sesquiterpenoid, named dysidotronic acid 1, with a rearranged drimane skeleton has been isolated from the sponge Dysidea sp. from Vanuatu islands, along with bolinaquinone 2. The chemical structure of 1 was determined on the basis of spectroscopic data. Dysidotronic acid significantly inhibited human synovial phospholipase A2 (PLA2) at 10 μM, with an IC50 value of 2.6 μM and a higher selectivity and potency towards this enzyme than the reference inhibitor manoalide.

year	journal	country	edition	language
2010-06-03	ChemInform

https://doi.org/10.1002/chin.200036194

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