Multivalente synthetische Glycopeptid-Lipopeptid-Antitumorvakzine: Auswirkung des Cluster-Effekts auf das Abtöten von Tumorzellen

6533b7d6fe1ef96bd1265a58

RESEARCH PRODUCT

Multivalente synthetische Glycopeptid-Lipopeptid-Antitumorvakzine: Auswirkung des Cluster-Effekts auf das Abtöten von Tumorzellen

Horst Kunz Yufen Zhao Mei-sha Chen Hui Cai Yan-mei Li Zhan-yi Sun

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Multivalente synthetische Vakzine wurden durch Festphasensynthese von tumorassoziierten MUC1-Glycopeptidantigenen und deren Kupplung an ein Pam3Cys-Lipopeptid durch Klick-Reaktion gewonnen. Diese Vakzine losen in Mausen Immunreaktionen aus, ohne dass externe Adjuvantien angewendet werden. Die vier MUC1-Sialyl-TN-Antigene enthaltende Vakzine zeigte einen signifikanten Cluster-Effekt. Sie induzierte in Mausen vorwiegend IgG2a-Antikorper, die an MCF-7-Brusttumorzellen binden und diese Tumorzellen durch Aktivierung des Complement-abhangigen Cytotoxizitatskomplexes (CDC) abtoten.

year	journal	country	edition	language
2014-01-21	Angewandte Chemie

https://doi.org/10.1002/ange.201308875

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