6533b7d6fe1ef96bd1265b55

RESEARCH PRODUCT

Pro-oxidant effects of 7-hydroperoxycholest-5-en-3β-ol on the copper-initiated oxidation of low density lipoprotein

Jean DavignonClaudia RodriguezDenis Blache

subject

Oxidized LDLLipid PeroxidesVery low-density lipoproteinTime FactorsOxysterolBiophysicsBiochemistryMedicinal chemistrychemistry.chemical_compoundOxysterolLipid oxidationStructural BiologyOxidationGeneticsHumansMolecular BiologyIntermediate-density lipoproteinCholesterolCell BiologyOxidantsPro-oxidantLipoproteins LDLCholesterolchemistryLow-density lipoproteinCholesterol hydroperoxidelipids (amino acids peptides and proteins)Oxidation-ReductionAged cholesterolCopperLipoprotein

description

AbstractIn low density lipoproteins (LDL) supplemented with aged cholesterol and oxidized in the presence of Cu2+, an increase of the lipid oxidation parameters was observed compared with pure cholesterol-enriched LDL. A compound, identified as 7-hydroperoxycholesterol (7HPC), isolated from aged cholesterol and added to LDL, reproduced the above effects. The results indicate that the pro-oxidant effect of 7HPC is dependent on the hydroperoxy group since the corresponding alcohol derivative, 7α-hydroxycholesterol, had no such effect. These data suggest that among the LDL-associated lipid peroxides, cholesterol peroxides may have important implications in the susceptibility of this lipoprotein to oxidation.

yearjournalcountryeditionlanguage
1995-01-03FEBS Letters
https://doi.org/10.1016/0014-5793(94)01348-5