6533b7d6fe1ef96bd1265b71
RESEARCH PRODUCT
Antitumour activity of mononuclear phagocytes: role of tumour necrosis factor alpha.
Mario SpataforaG. ChiapparaMario MelisElisabetta PaceMark GjomarkajAnna Maria Merendinosubject
Pulmonary and Respiratory MedicineCytotoxicity ImmunologicPhagocytesbusiness.industryTumor Necrosis Factor-alphamedicine.medical_treatmentCellTumour necrosis factor alphaOncolytic virusKiller Cells NaturalMajor Histocompatibility ComplexCytokinemedicine.anatomical_structureNeoplasmsImmunologymedicineCytotoxic T cellHumansTumor necrosis factor alphabusinessdescription
Tumour necrosis factor alpha (TNF) is a cytokine produced by mononuclear phagocytes (MP) originally discovered for its cytotoxic activity on tumour cell targets. It was subsequently demonstrated that, in addition to its oncolytic potential, TNF exerts a wide variety of activities on the host defensive system against malignancies. This article briefly reviews the current concepts on the role of TNF in the antitumour activity of MP.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 1992-01-01 | Respiration; international review of thoracic diseases |