6533b7d6fe1ef96bd1265bfd
RESEARCH PRODUCT
Axons take a dive
Cheuk Ka TongArantxa Cebrián-sillaEric J. HuangJosé Manuel García-verdugoMercedes F. ParedesArturo Alvarez-buyllasubject
Ependymal Cell1.1 Normal biological development and functioningBiologySerotonergicArticleLateral ventriclesDevelopmental NeuroscienceUnderpinning research2.1 Biological and endogenous factorshumanAetiologyneural stem cellsPlexusNeurogenesisNeurosciencesependymal cellsAnatomyStem Cell ResearchNeural stem cellserotoninsupraependymal axonsadult neurogenesisnervous systemNeurologicalSerotoninRaphe nucleiNeuroscienceDevelopmental Biologydescription
In the walls of the lateral ventricles of the adult mammalian brain, neural stem cells (NSCs) and ependymal (E1) cells share the apical surface of the ventricular-subventricular zone (V-SVZ). In a recent article, we show that supraependymal serotonergic (5HT) axons originating from the raphe nuclei in mice form an extensive plexus on the walls of the lateral ventricles where they contact E1 cells and NSCs. Here we further characterize the contacts between 5HT supraependymal axons and E1 cells in mice, and show that suprependymal axons tightly associated to E1 cells are also present in the walls of the human lateral ventricles. These observations raise interesting questions about the function of supraependymal axons in the regulation of E1 cells.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2014-01-01 | Neurogenesis |