6533b7d6fe1ef96bd1265ce1
RESEARCH PRODUCT
Characterisation of the essential oil of Nepeta glomerata Montbret et Aucher ex Bentham from Lebanon and its biological activities.
Carmen FormisanoNelly Apostolides ArnoldFederica MenichiniFilomena ConfortiFranco PiozziFelice SenatoreDaniela Riganosubject
LipopolysaccharidesPlant ScienceMicrobial Sensitivity TestsNitric OxideBiochemistryAnalytical Chemistrylaw.inventionchemistry.chemical_compoundMicelawNepetaCell Line TumorBotanyOils VolatileAnimalsHumansCarvacrolNo productionLebanonEssential oilbiologyOrganic ChemistryMs analysisbiology.organism_classificationAnti-Bacterial AgentschemistryMonoterpenesNepetaRenal adenocarcinomaDrug Screening Assays AntitumorAntibacterial activityBacteriadescription
The essential oil of Nepeta glomerata from Lebanon was studied by means of GC and GC/MS analysis; 70 compounds were identified. The oil was constituted mainly by monoterpenes and the most abundant components were α-pinene, spathulenol and carvacrol. Nepeta glomerata oil showed antibacterial activity, particularly towards Gram-positive bacteria, and also inhibited LPS-induced NO production in macrophage cell line RAW 264.7, with an IC(50) value of 78.1 µg mL(-1). Furthermore, an in vitro cytotoxic assay showed that the oil was more active on a renal adenocarcinoma cell line (48% of inhibition of proliferation at 100 µg mL(-1)) in comparison to an amelanotic melanoma.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2011-03-01 | Natural product research |