6533b7d6fe1ef96bd1265e4c

RESEARCH PRODUCT

Brain choline has a typical precursor profile.

Konrad Löffelholz

subject

ChemistryGeneral NeuroscienceBrainCholine acetyltransferaseAcetylcholineCholinechemistry.chemical_compoundKineticsMembraneBiochemistryPhysiology (medical)SynapsesmedicineExtracellularCholinergicCholineAnimalsHomeostasisHumansCholinergic mechanismsAcetylcholineHomeostasisPhospholipidsmedicine.drug

description

Choline is product and precursor to both acetylcholine and membrane phospholipids, and, in the brain, is ultimately provided by the circulation. The brain is protected from excess choline and choline deprivation by a refined system of homeostatic mechanisms that maintain a level of extracellular choline that, for its role as precursor, meets saturation criteria under normal conditions. The kinetic and activity profiles of choline are typical for a biosynthetic precursor.

yearjournalcountryeditionlanguage
1998-10-28Journal of physiology, Paris
10.1016/s0928-4257(98)80025-9https://pubmed.ncbi.nlm.nih.gov/9789815