Sekretorā IgA un zarnu mikrobioma mijiedarbība un dinamika antidiabētiskās terapijas laikā

6533b7d6fe1ef96bd1266048

RESEARCH PRODUCT

Sekretorā IgA un zarnu mikrobioma mijiedarbība un dinamika antidiabētiskās terapijas laikā

subject

Cukura diabēts Metformīns Bioloģija Zarnu mikrobioms Sekretorais IgA

description

Metformīns ir viens no visplašāk izmantotajiem medikamentiem 2.tipa cukura diabēta (T2D) ārstēšanā. Papildus glikozes izdales samazināšanai aknās un glikozes uzņemšanas palielināšanai muskuļos, arvien vairāk pierādījumu liecina, ka zarnu mikrobioms ir metformīna galvenā darbības vieta. Jaunākie pētījumi liecina, ka metformīns būtiski maina zarnu mikrobiomu T2D pacientiem. Sekretorajam IgA ir svarīga loma zarnu, elpceļu un uroģenitālās gļotādas epitēlija aizsardzībā un homeostatiskā regulēšanā, kā arī mijiedarbībā ar mikrobiomu. Metformīna terapijas laikā tika ievākti fēču paraugi no 19 jaundiagnosticētiem T2D pacientiem (trīs laika punktos) un astoņām veselām kontrolēm (divos laika punktos), kurus raksturoja, izmantojot visa metagenoma sekvenēšanu. Iegūtie rezultāti liecina, ka metformīna lietošana pēc trīs mēneša metformīna terapijas T2D pacientiem novērojams Roseburia, Alistipes un Rikenellaceae lielāks baktēriju īpatsvars (Presort paraugos) un Proteobacteria sIgA+ frakcijās. Veseliem indivīdiem ir novērojams Enterobacterales, Proteobacteria un Gammaproteobacteria lielāks baktēriju īpatsvars IgA+ frakcijās.

year	journal	country	edition	language
2022-01-01

https://dspace.lu.lv/dspace/handle/7/59252

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