6533b7d6fe1ef96bd1266b2f
RESEARCH PRODUCT
Lipase-catalysed preparation of acyl derivatives of the germacranolide sesquiterpenoid cnicin
Ln MonsalveSergio RosselliMaurizio BrunoA. Baldessarisubject
enzyme catalysis acylation alcoholysis sesquiterpenoids cnicinSettore CHIM/06 - Chimica Organicadescription
Several acyl derivatives of cnicin were obtained through lipase-catalysed acylation and alcoholysis reactions. In most reactions lipases showed a regioselective behaviour affording only one product. Longer chain acyl derivatives were prepared at lower temperature than the used in lipase-catalysed reactions, to preclude side products formation. The enzymatic approach let to prepare a family of novel acetyl and fatty acid derivatives of cnicin which are not obtainable following traditional organic synthetic procedures.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2009-01-01 |