Fluorimetric determination of captopril by flow injection analysis

6533b7d6fe1ef96bd1266ead

RESEARCH PRODUCT

Fluorimetric determination of captopril by flow injection analysis

J. Martínez Calatayud R. Segarra Guerrero S. Sagrado Vives

subject

Flow injection analysis Aqueous solution Chromatography Chemistry Fluorescence spectrometry Sulfuric acid Captopril Dosage form Analytical Chemistry Ion chemistry.chemical_compound medicine Spectroscopy medicine.drug

description

A flow injection analysis procedure is proposed for the determination of captopril. The sample solution was directly injected into the carrier-reagent stream which was prepared by a solution of ceric ions in 0.25 M sulfuric acid. The procedure is based on the fluorimetric monitoring of the formed Ce(III). Chemical, FIA, and instrumental parameters were optimized and the procedure is applied to the captopril determination in pharmaceutical formulations with competitive precision and adequate accuracy.

year	journal	country	edition	language
1991-06-01	Microchemical Journal

https://doi.org/10.1016/s0026-265x(10)80002-5

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