6533b7d6fe1ef96bd1266f5c
RESEARCH PRODUCT
Healon®5: A New Viscoadaptive Formulation
H. Burkhard DickOliver Schwennsubject
Shear (sheet metal)Shear rateMaterials scienceRheologyFlow (psychology)Shell (structure)MechanicsFrequency dependenceZero shear viscosityHigh flowdescription
To relate the practical relevance of our study results, specific requirement profiles for individual procedures have been correlated to the desired physicochemical characteristics. Healon®5 demonstrated the statistically significant highest zero shear viscosity of all OVD and a long relaxation time (Dick et al., 2000). It therefore most effectively creates and maintains a deep anterior chamber in order to facilitate safe surgical maneuvers (e.g., in case of vitreous pressure). Additionally, the high viscosity of Healon®5 exhibits a dynamic frequency dependence, which has not been observed in any pure hyaluronic acid formulation before. Healon®5’s properties change in response to surgical maneuvers. This rheological behaviour possibly reflects the facilitated removal of Healon®5. By means of introducing turbulences and phaco power (continuous high shear rates) creating a high flow situation, Healon®5 becomes less viscous over time by fragmentation. During surgery with high flow situations, it forms a cavity with an outer retentive shell. Healon®5 obtains both, dispersive as well as cohesive characteristics (Fig. 115).
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2000-01-01 |