A truncated driven Overhauser effect study of Adriamycin in water: Conformation of the glycosidic linkage

6533b7d7fe1ef96bd12678cf

RESEARCH PRODUCT

A truncated driven Overhauser effect study of Adriamycin in water: Conformation of the glycosidic linkage

E. Trotta Marcello Giomini M. Cirilli Anna Maria Giuliani

subject

chemistry.chemical_classification Aqueous solution General Engineering Spin–lattice relaxation Analytical chemistry Glycosidic bond Nuclear magnetic resonance spectroscopy Nuclear Overhauser effect Spectral line Crystallography symbols.namesake Fourier transform chemistry symbols

description

Abstract Truncated driven nuclear Overhauser effect difference spectra have been used to ascertain the conformational characteristics of the glycosidic linkage of Adriamycin in aqueous solution. The “two-spin approximation” has been employed to evaluate the cross-relaxation rates between nearby protons and to obtain the relative internuclear distances. The rotational angles φ1 = C(7)−O(7)−C(1′)−(H1′) and φ2 = H(7)−C(7)−O(7)−C(1′) have also been calculated.

year	journal	country	edition	language
1991-01-01	Spectrochimica Acta Part A: Molecular Spectroscopy

https://doi.org/10.1016/0584-8539(91)80147-b

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