6533b7d7fe1ef96bd126830b
RESEARCH PRODUCT
ChemInform Abstract: Assignment of the Absolute Configuration and Total Synthesis of (+)-Caripyrin.
Till OpatzLars Andernachsubject
symbols.namesakeComputational chemistryChemistryBoltzmann constantVibrational circular dichroismAbsolute configurationEnantioselective synthesissymbolsTotal synthesisGeneral MedicineSpectroscopyConformational isomerismDextrorotatorydescription
The antifungal secondary metabolite (+)-caripyrin was studied by vibrational circular dichroism spectroscopy. Analysis of the recorded data, with the Boltzmann weighted-average of the spectra calculated at the B3LYP/6-311G(d,p) level of theory for all relevant conformers, unequivocally proved the (R,R)-configuration for the dextrorotatory natural product. Based on this finding, a short enantioselective synthesis of (+)-caripyrin was developed.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2015-02-19 | ChemInform |