6533b7d7fe1ef96bd1268346

RESEARCH PRODUCT

Nitric Oxide Is a Promising Enhancer for Cancer Therapy

Néjia SassiAli BettaiebMarion CortierJean-françois JeanninLissbeth LeonCatherine Paul

subject

Chemotherapybusiness.industrymedicine.medical_treatmentCancer therapyNitric oxideIonizing radiationchemistry.chemical_compoundCytokinemedicine.anatomical_structurechemistryApoptosismedicineCancer researchbusinessEnhancerSensitization

description

This report summarizes the present state of our knowledge pertaining to the nitric oxide (NO)-induced sensitization of tumor cell death. The effects of NO and its synergy with ionizing radiations, with members of the TNF family, and with chemotherapy have been investigated. The effect of NO-induced sensitization and the underlying molecular mechanisms are discussed.

https://doi.org/10.1007/978-1-4419-1432-3_13