6533b7d7fe1ef96bd1268524
RESEARCH PRODUCT
Functions of SETD7 during development, homeostasis and cancer
Natalia Soshnikovasubject
0301 basic medicineRegulation of gene expressionCellular differentiationCellSUMO proteinRNABiologyEmbryonic stem cellCell biology03 medical and health sciencesEditorial Commentary030104 developmental biology0302 clinical medicinemedicine.anatomical_structure030220 oncology & carcinogenesismedicineStem cellOrganismdescription
A controlled organ homeostasis is essential to sustain the integrity of any living organism. This homeostasis relies on stem cells, which maintain themselves and give rise to the various types of differentiated cells. It is well established that the differentiation of pluripotent embryonic stem cells (ESCs) depends on major changes in transcriptional programs. Covalent modifications of DNA, RNA and proteins are instrumental in setting up the genetic programs associated with cell fates. Another important mechanism for regulation of gene expression is protein localisation and stability. In addition to ubiquitination, SUMOylation and phosphorylation, methylation of proteins is an important determinant of their properties.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2019-09-01 |