6533b7d7fe1ef96bd1268584
RESEARCH PRODUCT
Antiproliferative activity of hexane extract from Tunisian Cistus libanotis, Cistus monspeliensis and Cistus villosus
Giuseppina AutoreMohamed Elyes KchoukFelice SenatoreMariem Ben JemiaStefania MarzoccoVincenzo De FeoMaurizio Brunosubject
Cistus villosuChemistry(all)MonoterpeneCistus libanotischemistry.chemical_compoundCistusCistus monspeliensiSettore BIO/15 - Biologia FarmaceuticaCistus monspeliensisMedicinal plantsHexane extractbiologyTraditional medicineC. villosuC. monspeliensiSettore CHIM/06 - Chimica OrganicaGeneral ChemistryPreliminary Communicationbiology.organism_classificationAntiproliferative activity in vitroHexanechemistryPhytochemicalCistus libanotiHuman melanomaGC-MSdescription
Abstract Background As a part of our investigation on Tunisian medicinal plants, we have carried out a phytochemical investigation of the hexane extracts from leaves of Cistus libanotis, C. villosus and C. monspeliensis, evualuating also their possible antiproliferative activity in vitro. Results The major compounds of hexane extracts were identified and quantified by GC-MS. The composition of the three species, although belonging to the same genus, is completely different. The antiproliferative activity was evaluated against murine monocyte/macrophages (J774.A1), human melanoma cells (A-375), and human breast cancer cells (MCF-7), showing major activity against the human melanoma cell line A-375. Conclusions The chemical composition of the hexane extracts from the three Cistus species can be useful in the chemosystematics of this complex genus. The preliminary antiproliferative activity against human melanoma cell line A-375 deserve further investigations in order to determine the compounds, or their combinations, which are the main responsible for the antiproliferative activity and its possible mechanism(s) of action.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2013-01-01 | Chemistry Central Journal |