Aripiprazola un olanzapīna ietekme uz kognitīvajām funkcijām apomorfīna uzvedības modelī

6533b7d7fe1ef96bd1268950

RESEARCH PRODUCT

Aripiprazola un olanzapīna ietekme uz kognitīvajām funkcijām apomorfīna uzvedības modelī

Kristaps Dzenis

subject

description

Šizofrēniju ārstē ar antipsihotiskām vielām, kuru blaknes ir kognitīvo funkciju pasliktināšanās, kas ir ļoti nozīmīga problēma šizofrēnijas slimnieku sociālās aprūpes iznākumā. Tādēļ tiek meklēti jauni antipsiohotiskie līdzekļi, kas neietekmētu kognīciju. Aripiprazols un olanzapīns ir jaunās paaudzes antipsihotiskās vielas, kas varētu būt pārākas par citiem aģentiem, ja neietekmētu kognitīvo funkciju. Šī pētījuma mērķis bija novērtēt aripiprazola un olanzapīna ietekmi uz kognitīvajām funkcijām apomorfīna izraisītas šizofrēnijas modelī. Iegūtie rezultāti liecina, ka aripiprazols un olanzapīns samazina izvairīšanos no strāvas sitiena skaitu Shuttle Box testā, bet olanzapīns samazina izbēgšanu skaitu. Aripiprazols pagarināja latento periodu Step Through testā. Rezultāti liecina, ka abas antipsihotiskās vielas tomēr ietekmē kognitīvo funkciju, jo pasliktina darba atmiņu, uzmanību un atmiņu. Atslēgvārdi: aripiprazols, olanzapīns, apomorfīns, šizofrēnija

year	journal	country	edition	language
2014-01-01

https://dspace.lu.lv/dspace/handle/7/22429

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