6533b7d7fe1ef96bd1268ca3

RESEARCH PRODUCT

The role of NFkappaB inducing kinase (NIK) in the pathogenicity of EAE

Florian MairBurkhard BecherSabrina RodewaldNicole IsraelSonja M. LacherAri Waisman

subject

VAV3DDR1MicroarrayKinaseImmunologyPTPN6Biologymedicine.disease_causedigestive systemdigestive system diseasesCell biologysurgical procedures operativeNeurologybiology.proteinmedicineImmunology and AllergyPhosphorylationNeurology (clinical)STAT3Oxidative stress

description

pathways (PTPN6, SLC3A2, VAV3, DDR1) and modulators of oxidative stress (MT1A, HMOX1, SLC30A1) were also significantly affected by the CBD treatment. The microarray results were confirmed using qPCR on selected gene targets. Immunoblotting demonstrated that CBD reduces IL-17 by decreasing STAT3 phosphorylation and increasing that of STAT5. In conclusion, our observations increase our understanding of the mechanisms of the anti-inflammatory activities of CBD.

yearjournalcountryeditionlanguage
2014-10-01Journal of Neuroimmunology
https://doi.org/10.1016/j.jneuroim.2014.08.542