6533b7d7fe1ef96bd1268ec0
RESEARCH PRODUCT
A Case of Follicular Tumor of Uncertain Malignant Potential (FT-UMP) with Glomeruloid Features Showing Capsular Mucinous Degeneration
Calogero CipollaGiuseppa GraceffaAndrea MondelloAda Maria FlorenaMaria Rosaria ValerioGiulia RimiDaniela CabibiAntonino Giulio Giannonesubject
Capsular InvasionPathologymedicine.medical_specialtyendocrine systemStromal cell030209 endocrinology & metabolismCase ReportSettore MED/08 - Anatomia PatologicaMucinous degenerationWorld healthThyroid carcinomaGlomeruloid Features03 medical and health sciences0302 clinical medicineFollicular phasemedicinePathologyEndocrine systemRB1-214Follicular Tumor of Uncertain Malignant Potential (FT-UMP)business.industryGeneral MedicineStainingSettore MED/18 - Chirurgia Generale030220 oncology & carcinogenesisbusinessdescription
The most recent revision of the World Health Organization (WHO) Classification of Tumours of Endocrine Organs introduced a new variant of follicular thyroid carcinoma (FTC). It is characterized by a “glomeruloid” architectural pattern of growth. We present a case of follicular tumor with glomeruloid features, with Alcian Blue positive mucinous stromal degeneration in foci of questionable capsular microinvasion. At our knowledge, this the second case of glomeruloid follicular tumor in the literature and the first case in which Alcian Blue staining was used to investigate capsular invasion. Moreover, RAS mutation further supports that this is a variant of follicular tumor with uncertain malignant potential.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2021-01-01 | Case Reports in Pathology |