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RESEARCH PRODUCT

Genotyping and Antifungal Susceptibility of Dipodascus capitatus Isolated in a Neonatal Intensive Care Unit of a Sicilian Hospital

Dario LipariGiuseppa PinelloGiovanni CorselloGiuseppe AquilinaCinzia CalàGiuseppina CapraTeresa FascianaAnna GiammancoIngrid Anne Mandy SchierzMario Giuffrè

subject

0301 basic medicineAntifungalGenotypingPediatricsmedicine.medical_specialtyClonal disseminationNeonatal intensive care unitmedicine.drug_class030106 microbiologyDipodascus03 medical and health sciencesEpidemiologymedicineDipodascus capitatuAntifungal SusceptibilityDipodascus capitatusGenotypingBiochemistry Genetics and Molecular Biology (all)biologyMedicine (all)MicafunginAntifungal Susceptibility; Dipodascus capitatus; Genotyping; Nosocomial Acquisition; Cross Infection; Dipodascus; Female; Genotype; Hospitals; Humans; Infant; Infant Newborn; Intensive Care Units Neonatal; Male; Mycoses; Sicily; Medicine (all); Biochemistry Genetics and Molecular Biology (all)biology.organism_classificationNosocomial AcquisitionAntifungal Susceptibility; Dipodascus capitatus; Genotyping; Nosocomial Acquisition; Medicine (all); Biochemistry Genetics and Molecular Biology (all)medicine.drug

description

In August 2015, Dipodascus capitatus was isolated from two patients admitted to the neonatal intensive care unit. Nosocomial acquisition of the fungus was suspected and epidemiological studies were undertaken. The patients were simultaneously hospitalized, and the comparison of the two isolates by two independent molecular typing methods have confirmed clonal dissemination of a single strain of D. capitatus. Antimicrobial susceptibility testing was useful for identifying the appropriated antifungal therapy in micafungin. To our knowledge these are the first described cases of neonatal D. capitatus infection and also the first report of successful treatment by micafungin.

yearjournalcountryeditionlanguage
2017-01-01
https://doi.org/10.1007/5584_2016_195