6533b7d7fe1ef96bd1268f82
RESEARCH PRODUCT
Chromogenic Chemodosimeter Based on Capped Silica Particles to Detect Spermine and Spermidine
Mariana BarrosAna M. CosteroPablo GaviñaAlejandro López-carrascoSalvador GilMargarita ParraPedro AmorósJamal El HaskouriMaría Carmen Terenciosubject
Aqueous solutionsperminesilica particlesChemistryChromogenicGeneral Chemical EngineeringdetectionSpermineArticleSpermidineRhodamine 6GHydrophobic effectlcsh:Chemistrychemistry.chemical_compoundlcsh:QD1-999Covalent bondspermidineGeneral Materials ScienceTitrationNuclear chemistrydescription
A new hybrid organic–inorganic material for sensing spermine (Spm) and spermidine (Spd) has been prepared and characterized. The material is based on MCM-41 particles functionalized with an N-hydroxysuccinimide derivative and loaded with Rhodamine 6G. The cargo is kept inside the porous material due to the formation of a double layer of organic matter. The inner layer is covalently bound to the silica particles, while the external layer is formed through hydrogen and hydrophobic interactions. The limits of detection determined by fluorimetric titration are 27 µM and 45 µM for Spm and Spd, respectively. The sensor remains silent in the presence of other biologically important amines and is able to detect Spm and Spd in both aqueous solution and cells.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2021-03-23 | Nanomaterials |