6533b7d7fe1ef96bd1269142

RESEARCH PRODUCT

BODIPY dyes functionalized with 2-(2-dimethylaminophenyl)ethanol moieties as selective OFF–ON fluorescent chemodosimeters for the nerve agent mimics DCNP and DFP

Ramón Martínez-máñezAlejandro LorenteLuis E. OchandoAna M. CosteroRaúl GotorPablo GaviñaKatherine Chulvi

subject

General Chemical EngineeringBiological Warfare Agentschemistry.chemical_compoundOrganophosphorus HydrolasemedicineOrganic chemistryReactivity (chemistry)Nerve agentEthanolDmmp DetectionQUIMICA INORGANICAOptical-PropertiesAqueous two-phase systemGeneral ChemistryCombinatorial chemistryFluorescenceElectrochemical gas sensorchemistryAcetylcholinesteraseSpectroscopic PropertiesBODIPYPhotonic CrystalBiosensorElectrochemical SensorDerivativesBiosensormedicine.drug

description

[EN] Two OFF-ON fluorescent chemodosimeters based on a BODIPY core for the detection of nerve agent mimics have been synthesized. Their reactivity towards diethylcyanophosphonate (DCNP) and diisopropylfluorophosphate (DFP) has been tested in organic and aqueous phase. These chemodosimeters selectively detect the nerve agent mimics with good LODs. The chemodosimeters hold their sensing properties on solid supports, allowing the preparation of a hand held sensing kit. The sensing in solid-liquid phase has been demonstrated. The X-ray structure of compound 2 has been resolved.

yearjournalcountryeditionlanguage
2014-01-01RSC Adv.
https://doi.org/10.1039/c4ra00710g