6533b7d8fe1ef96bd1269801
RESEARCH PRODUCT
Hyaluronic Acid in the Treatment of Pain Due to Knee Joint Immobilisation
G. A. LetiziaCarmelo Di Marcosubject
medicine.medical_specialtybusiness.industrySignificant differenceReduced mobilityGeneral MedicineKnee JointSurgerychemistry.chemical_compoundchemistryJoint mobilityUntreated controlJoint stiffnessHyaluronic acidmedicinePharmacology (medical)medicine.symptomAdverse effectbusinessdescription
This open, randomised study was carried out in order to evaluate the safety and efficacy of a course of 5 intra-articular injections (one per week) of hyaluronic acid (HA), administered to patients with pain and joint stiffness resulting from immobilisation of the knee in a plaster cast. The study was made in comparison with an untreated control group. 30 patients of both genders, aged between 18 and 65 years, immobilised in a plaster cast for at least 20 days and presenting with pain and reduced mobility, were included in the study. The results of the study show that, in comparison with the control group, treatment with HA produced a more rapid and effective reduction in pain and increase in joint mobility. A significant difference between groups for all the parameters of efficacy was seen from the 21st day up to the end of the study on the 45th day. No adverse events were observed during the follow-up period.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 1995-10-01 | Clinical Drug Investigation |