6533b7d8fe1ef96bd12699c1
RESEARCH PRODUCT
IL-6 trans-Signaling
Markus F. NeurathStefan Rose-johnsubject
Tissue sectionsInfectious DiseasesBiochemistrybiologyImmunologybiology.proteinTrans signalingImmunology and AllergyAdhesionInterleukin 6ReceptorHeat responsesCell biologydescription
The molecular consequence of the fever response has been illuminated by a recent study showing that a temperature shift to 40 degrees C resulted in increased leukocyte adhesion to tissue sections, which was mediated by L-selectin activation in lymphocytes. This L-selectin activation during heat responses was dependent on IL-6 trans-signaling via the soluble IL-6R.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2004-01-01 | Immunity |