6533b7d8fe1ef96bd1269ad4

RESEARCH PRODUCT

Dehydration of detomidine hydrochloride monohydrate

A. ActiņšJ. JaunbergsK. Veldre

subject

Phase transitionDetomidineDifferential Thermal AnalysisChemistryImidazolesAnalytical chemistryPharmaceutical SciencePhase TransitionIsothermal processKineticsDrug StabilityModels ChemicalX-Ray DiffractionDifferential thermal analysisPhase (matter)Adrenergic alpha-2 Receptor AgonistsmedicineThermodynamicsChemical stabilityDesiccationThermal analysisPowder DiffractionPowder diffractionmedicine.drug

description

The thermodynamic stability of detomidine hydrochloride monohydrate has been evaluated on the basis of phase transition kinetics in solid state. A method free of empirical models was used for the treatment of kinetic data, and compared to several known solid state kinetic data processing methods. Phase transitions were monitored by powder X-ray diffraction (PXRD) and thermal analysis. Full PXRD profiles were used for determining the phase content instead of single reflex intensity measurements, in order to minimize the influence of particle texture. We compared the applicability of isothermal and nonisothermal methods to our investigation of detomidine hydrochlorine monohydrate dehydration.

yearjournalcountryeditionlanguage
2010-11-06European Journal of Pharmaceutical Sciences
https://doi.org/10.1016/j.ejps.2011.08.004