6533b7d8fe1ef96bd1269b30
RESEARCH PRODUCT
Controlled release using mesoporous materials containing gate-like scaffoldings.
Elena AznarFélix SancenónRamón Martínez-máñezsubject
Models MolecularDrug CarriersMaterials scienceSilicon dioxidePharmaceutical ScienceNanotechnologyMesoporous silicaSilicon DioxideControlled releaseNanostructureschemistry.chemical_compoundMesoporous organosilicaDrug Delivery SystemschemistrySpecific surface areaDelayed-Action PreparationsMesoporous materialHybrid materialDrug carrierPorositydescription
The use of gated mesoporous silica solids as suitable systems for controlled-release protocols is reviewed. These materials are based on mesoporous silica supports that can be prepared with tailor-made pores of around 2 - 10 nm and that show a very large specific surface area (up to 1200 m(2)/g), thus having a large load capacity. The solids can be additionally functionalised in the external surface with gate-like systems that can be opened on command to allow cargo release. Light, redox reactions, pH, temperature, polarity and enzyme-driven protocols are shown. The possible application in drug delivery protocols is discussed.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2009-06-01 | Expert opinion on drug delivery |