6533b7d8fe1ef96bd126a199
RESEARCH PRODUCT
Hyaluronic Acid-g-Copolymers: Synthesis, Properties, and Applications
Giovanna PitarresiFabio Salvatore PalumboGaetano GiammonaGaetano GiammonaCalogero Fioricasubject
chemistry.chemical_classificationchemistry.chemical_compoundBiocompatibilitychemistryTissue engineeringHyaluronic acidSelf-healing hydrogelsNanomedicineNanotechnologyPolymerNanocarriersRegenerative medicinedescription
The aim of this chapter is to review hyaluronic acid (HA) graft copolymers focusing in the description of chemical strategies employed for their synthesis, characterization procedures, and applications in biomedical and pharmaceutical field. Usually biocompatible synthetic polymers and peptides with therapeutic activity are grafted to HA to modify in appropriate way the physicochemical properties of the starting polysaccharide for a specific purpose and at the same time to exploit its biological role, biocompatibility, and targeting ability toward cells with receptors for HA. The use of such HA graft copolymers in the production of nanocarriers or hydrogels for modified drug release and scaffolds for regenerative medicine will be outlined.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2013-01-01 |