6533b7d8fe1ef96bd126a233
RESEARCH PRODUCT
Uptake and Metabolism of Purine Nucleosides and Purine Nucleoside Analogues by Cells
Werner E.g. Müllersubject
Purinechemistry.chemical_classificationbiologyPurine nucleoside phosphorylasePurine analogueGuanosinechemistry.chemical_compoundInosinic acidAdenosine deaminasechemistryBiochemistrybiology.proteinNucleotideNucleosidedescription
Since the discovery of purine nucleotides and purine nucleosides, 1847 by Liebig (1) (inosinic acid) and 1885 by Schulze et al. (2) (guanosine),it was only relatively recently that purine- and purine-nucleoside analogues have been considered to be effective antitumor or antiviral agents. It is due to Prusoff, Schabel and S.S. Cohen that on the other hand pyrimidine nucleoside analogues have already been used clinically as drugs for a number of years.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 1979-01-01 |