6533b7d8fe1ef96bd126a290

RESEARCH PRODUCT

1,4-regioselective iodofunctionalizations of 1,3-butadiene

José M. GonzálezJosé BarluengaPedro J. CamposGregorio Asensio

subject

Addition reactionchemistry.chemical_compoundchemistryOrganic ChemistryDrug DiscoveryRegioselectivityOrganic chemistry13-ButadieneAcid treatmentBenzeneAcetonitrileBiochemistry

description

Abstract Addition reactions of benzene and acetonitrile to 1,3-butadiene are described. This new iodofunctionalization process proceeds “via” iodonium ion-allylic cation equilibrium and gives regioselectively 1,4-adducts, which can be alternatively obtained by acid treatment of the 1,2-derivative 8 .

https://doi.org/10.1016/s0040-4039(00)82383-7